ARCA biopharma (NASDAQ: ABIO) today announced a new development program to evaluate AB201 (“rNAPc2”), a potent, selective inhibitor of tissue factor (“TF”), as a potential treatment for COVID-19 associated coagulopathy (“CAC”) and the related inflammatory response. According to the update, CAC is one of the most serious adverse effects seen in COVID-19 patients. “During this global health crisis, we believe it is important to rapidly and collaboratively evaluate multiple technologies to address COVID-19 and the associated pathologic host responses,” Dr. Michael Bristow, ARCA’s president and CEO, who is also an American Heart Association (“AHA”) funded COVID-19 investigator, stated in the news release. “The combination of anticoagulation, anti-inflammatory effects and antiviral activity have the potential to make AB201 a unique therapeutic to treat patients afflicted with COVID-19 while vaccine development is underway and for patients for whom a vaccine is not effective. We believe this therapeutic approach may also have potential to address future outbreaks of diseases related to other RNA viruses.”
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About ARCA biopharma
ARCA biopharma is dedicated to developing genetically targeted therapies for cardiovascular diseases through a precision medicine approach to drug development. ARCA is developing AB201 as a potential treatment for diseases caused by RNA viruses, initially focusing on COVID-19. ARCA is also developing Gencaro(TM) (bucindolol hydrochloride), an investigational, pharmacologically unique beta-blocker and mild vasodilator, as a potential treatment for atrial fibrillation in heart failure patients. ARCA has identified common genetic variations that it believes predict individual patient response to Gencaro, giving it the potential to be the first genetically targeted AF prevention treatment. The U.S. FDA has granted the Gencaro development program Fast Track designation and a Special Protocol Assessment (“SPA”) agreement. For more information, please visit www.ARCABio.com.
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