Lantern Pharma (NASDAQ: LTRN) and its wholly owned subsidiary, Starlight Therapeutics, announced the publication of Phase 1a clinical data for LP-184 (zirdafulven), also being developed as STAR-001, in patients with recurrent glioblastoma (“GBM”). Published in the October 2026 issue of Cancer Research Communications, the study evaluated 16 patients and found LP-184 was generally well tolerated, establishing a recommended expansion dose of 0.39 mg/kg. No objective radiographic responses were observed, although one patient remained clinically and radiographically stable for more than 22 months after enrollment. The findings also identified limited drug exposure in brain tumors, supporting further evaluation of LP-184 in combination with spironolactone, an FDA-approved drug that reduced the concentration of LP-184 needed to kill GBM cells by threefold to sixfold in preclinical models.
The company said the findings establish a dosing rationale for a planned Phase 1b/2a trial evaluating LP-184 plus spironolactone in patients experiencing their first GBM recurrence. The study, sponsored by Starlight Therapeutics under an FDA-cleared Investigational New Drug application, will assess safety, pharmacokinetics and objective response. The combination strategy was developed with support from Lantern’s RADR(R) AI platform and research collaborators at Johns Hopkins University. LP-184 has received FDA Fast Track Designation for GBM and triple-negative breast cancer, along with Orphan Drug Designations for certain central nervous system cancers.
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About Lantern Pharma
Lantern Pharma (NASDAQ: LTRN) is a clinical-stage biopharmaceutical company leveraging its proprietary RADR artificial intelligence and machine-learning platform to transform the cost, pace, and precision of oncology drug development. By integrating large-scale genomic and biological data with advanced machine learning, RADR is designed to identify the patients most likely to benefit from Lantern’s therapies and to guide biomarker-driven clinical development. The company’s pipeline includes LP-184 (zirdafulven), LP-300, and LP-284, along with its central-nervous-system-focused subsidiary, Starlight Therapeutics, and its AI subsidiary, Open-Medicine AI.
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